What is Glimepiride?
Generic Glimepiride is an oral antidiabetic drug. Second-generation sulfonylurea drugs cause less pancreatic exhaustion, reduce the risk of hypoglycemia, and Glimepiride is less likely to cause weight gain compared to other hypoglycemic drugs. Glimepiride rarely causes cardiovascular complications. The action of the drug starts quickly and is well absorbed. The elimination half-life of Glimepiride is 5-9 hours.
Glimepiride is prescribed for type 2 diabetes that is difficult to control with diet and physical exercises only, as monotherapy or in combination with Metformin, insulin or other oral or injectable antidiabetic drugs.
Dosage of Glimepiride
The dosage of Glimepiride is set individually based on regular monitoring of blood glucose concentrations.
If the patient has a hypoglycemic reaction when taking 1 mg of Glimepiride per day, this indicates that adequate control of blood glucose levels can only be achieved by following a proper diet low in easily digestible carbohydrates.
Blood and urine glucose concentrations should be measured regularly during treatment. In addition, it is recommended that the proportion of glycosylated hemoglobin be determined regularly.
If the patient forgot to take the next dose of the drug, it should not be increased at the next intake. If an accidental dose of Glimepiride is taken in excess of the recommended dose, it should be immediately reported to the physician.
Conditions that may also require adjustment of the dose of Glimepiride:
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decreased body weight in patients;
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changes in the patient's lifestyle (changes in diet, regular meals, amount of physical activity);
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occurrence of other factors that lead to the development of hypoglycemia or hyperglycemia.
Treatment with Glimepiride 2 mg is usually carried out for a long time, only the doctor can cancel the drug.
Typically, the initial dose is 1 mg once a day. If necessary, the daily dose may be increased. When increasing the dose of the drug, it is necessary to consider the concentration of glucose in the blood and increase the dose gradually, at intervals of one to two weeks as follows: 1 mg - 2 mg - 3 mg - 4 mg - 6 mg.
Maximum dose of Glimepiride
The maximum daily dose of Glimepiride is 6 mg, and it is not recommended to exceed it. It is recommended to take Glimepiride before a large meal (frequently before breakfast). It is very important not to skip meals after taking the drug.
Contraindications of Glimepiride
Glimepiride is not prescribed for the following conditions:
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stressful situations (severe trauma, burns, surgery, severe infections with fever, septicemia)
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exhaustion, starvation, following a hypocaloric diet (less than 1000 kcal/day)
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disorders of absorption of food and drugs in the gastrointestinal tract (with intestinal obstruction, intestinal paresis, diarrhea, vomiting)
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chronic alcoholism, acute alcohol intoxication
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galactose deficiency and intolerance, glucose-galactose malabsorption (because the drug contains lactose monohydrate)
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diabetes of the first type
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diabetic ketoacidosis, diabetic precoma and coma
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leukopenia
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severe abnormalities of the liver
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severe renal dysfunction (especially if the patient is on hemodialysis)
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hypersensitivity to Glimepiride or any additional component of the drug, to other sulfonylurea derivatives or to sulfonamides (risk of hypersensitivity reactions)
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pregnancy and lactation
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childhood under 18 years of age
Glimepiride reduces the concentration and speed of psychomotor reactions of the patient. This may adversely affect the ability to drive vehicles or operate various machines and mechanisms. Therefore, during treatment with this drug, it is better to refrain from driving a car.
Glimepiride and alcohol
Alcohol can cause a decrease in blood sugar levels not only immediately after consumption, but also 24 hours later, which can lead to dangerous side effects.
Taking Glimepiride and alcohol at the same time increases the risk of lacto acidosis, which causes lactic acid to build up in the blood and can lead to symptoms such as nausea and weakness.
Sulfonylurea drugs interact with alcohol and cause dizziness, nausea, and low blood glucose levels, which can lead to fainting and even death if not treated in time. It is important to stop drinking alcohol and seek medical attention.
Overdose
After ingestion of a large dose of Glimepiride, hypoglycemia may develop, lasting from 12 to 72 hours, which may recur after the initial recovery of blood glucose concentrations. In most cases, observation under hospital conditions is recommended. Increased sweating, anxiety, tachycardia, increased BP, palpitations, heart pain, arrhythmia, headache, dizziness, increased appetite, nausea, vomiting, apathy, sleepiness, restlessness, aggressiveness, concentration disorders, depression, confusion, tremors, paresis, sensitivity disorders, convulsions of central genesis may occur. Sometimes the clinical picture of hypoglycemia may resemble a stroke. Development of coma is possible.
Treatment: includes induction of vomiting, copious drinking with activated carbon (adsorbent) and sodium picosulfate (laxative). If a large amount of Glimepiride is taken, gastric lavage is indicated, followed by administration of sodium picosulfate and activated charcoal. As soon as possible begin administration of Dextrose, if necessary in the form of 50 ml of 40% solution by injection, followed by infusion of 10% solution, with careful monitoring of blood glucose concentration. Further treatment should be symptomatic.
Does Glimepiride cause hypoglycemia?
Glimepiride may cause a sharp decrease in blood glucose levels if used improperly and in excess of the dosage.
It can be difficult to distinguish between ordinary intoxication and hypoglycemia, because the symptoms of these conditions are similar. Usually, when there is a sharp drop in blood sugar levels, the diabetic is disturbed by:
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tremors of the hands (begin to shake);
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increased sweating;
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severe headaches;
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dizziness;
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vomiting;
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recurrent nausea;
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confusion;
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difficulties with orientation in space;
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speech disorders (becoming slurred and incoherent).
If symptoms of precoma have been observed, the following pre-hospital care should be performed:
1. Give the patient a sweet candy
2. Feed food that is high in carbohydrates
3. It is acceptable to give the patient a sweet tea or fruit drink
In case of loss of consciousness, more active actions are required to prevent the person's condition from worsening. A clear course of action should be followed, which includes the following principles of emergency care for hypoglycemic coma:
1. The unconscious person should be placed on his or her side.
2. If there are pieces of food (vomit) or other objects in the mouth, remove them.
3. Call an ambulance.
If the patient with diabetes mellitus often has a hypoglycemic state, it contributes to rapid vascular damage to the eyes (retinopathy).
It also frequently affects the cardiovascular system and the brain, which can lead to heart attack and stroke. That is why sudden hypoglycemia should not be allowed, and pre-hospital care should be provided in time.
The best time to take Glimepiride
Glimepiride is frequently prescribed once a day. Take this medicine with meals. Most people take Glimepiride in the morning during breakfast.
Can I take Glimepiride on an empty stomach?
Never take Glimepiride on an empty stomach, because the drug may lower glucose in the blood to critical levels.
The drug can be ordered in our pharmacy. The description shows Glimepiride price, availability, and basic information.
Since we are a Registered and Licensed Mexican pharmacy we assure you top quality medicines without the worry of your health care provider, employer or any other group finding out what rightfully is a private issue.
Did you know that your private medical file can be used against you to raise your insurance rates or in some cases and countries to lose your job? We take your privacy very seriously and by using these payment methods and the way in which we use them your bank does not directly get charged from our pharmacy. This way your medical needs stay as private as possible.
You will also receive a complete invoice in your email with payment totals and simple payment instructions toward the bottom of the email should you wish to pay at a later convenience.
IMPORTANT: If you need to make some changes in regards an existing order, contact us within 24 hours, otherwise, Meds Mex is not liable due to errors on customer’s information or products presentation.
Shipping Methods.
To ensure the delivery of your order we handle EXPRESS SHIPPING only. Signature is required.
Tracking numbers for all orders will be sent with instructions once shipped.
How long does it take to ship the drugs to my home or office?
- Express USA time frame: 10-21 business days. ($24.95 USD Signature required)
- Express World Wide time frame: 15-30 business days. ($39.95 USD Signature required)
*Due to unexpected Postal Service changes, one of the shipping methods above could be temporarily disabled.
IMPORTANT: Please ensure your mail program is configured to accept email from info@medsmex.com.mx sender, add our email to your non blocked email address so we may send invoices, order status and shipping confirmations. If you do not receive your invoice immediately after this, please check your spam filter and make necessary changes.
We reply promptly to your enquiries and requests emails, but are too busy to repeatedly resend email that customers do not receive because our replies have been moved to a customers’ Spam, Junk or Bulk email folder.
Online pharmacy Medicines Mexico shipping terms and conditions.
Our team endeavors to process all orders and ship within 72 business hours. All credit card and electronic check payments for your Mexico medicine take 24 to 48 hours to be approved by our Payment Processor; upon verification your order will be processed. If there are any problems with your order, we will contact you, so please ensure the email address and phone number you provide is correct, and that any spam filtering software you use accepts email from info@medsmex.com.mx
Express Shipping.
We offer Mex Post Express Shipping as an option. This option costs from $24.95 depending on the quantity of medications in your order (up to 9 medications). This option requires a customer signature on delivery. For all other locations Express Shipping is $39.95. All packages are shipped in plain packaging to guarantee your privacy. All packages are sent by parcel express mail from Mexico. Some parcels require a signature upon delivery at our discretion. There are no other handling fees, drug dispensing fees, or Mexican customs charges. If two or more people are ordering their prescription drugs from the same address at the same time, you will be billed for only one shipping charge from our Mexico pharmacy, up to our maximum order quantities limited by customs to 90 day supply. We are able to provide a tracking number on your express shipping parcels. If after 30 business days your order has not arrived, first check with your local postal office to ensure that your package is not being held for pick-up. If you still have problems, please contact us by email and we will attempt to assist you.
Notice Left
If no one is at home at the time of delivery, the status of you order on the Postal System will be updated to “Notice Left” which means USPS attempted to deliver your item and a notice was left because an authorized recipient was not available. You may arrange redelivery by visiting or calling 800-ASK-USPS, or may pick up the item at the Post Office indicated on the notice. If this item is unclaimed after five days then it will be returned to the sender. You can pay for reshipping $24.95 in order to receive a new tracking number. (Reshipping will be issued until the package is received back in our offices).
Holidays
Note that on Holidays season, the Mexican Postal, USA and other countries will be extra busy; therefore a delay is expected in packages shipped during this season. You will need to consider as well the Mexican holidays. We appreciate your understanding, our customer service will be happy to assist you and available to inform you the latest status on your existing order shipped, you can always contact us at Toll Free number or email address.
Order Cancellation
Due to our policy of same day payment processing, ORDERS CANNOT BE CANCELLED.
Returns
Due to government regulations and the possibility of tampering with medications, returns cannot be accepted. In case your package is returned due to no one was available to sign for it. You can pay for reshipping $24.95 in order to receive a new tracking number. (Reshipping will be issued until the package is received back in our offices).
How to find the online pharmacy drug you need.
There are many more medications available in Mexico that are not listed on our website. If you can’t find the Mexican drug or medication you require, please contact us and we may be able to help. Some products are listed only in a single dosage size or medicine type, but may be available in other dosages and forms. Our experienced Mexican pharmacy Pharmacists will do their best to accommodate your requirements. Please always specify the chemical name of the medication (and any applicable brand name) with all inquiries. Please feel free to ask about ANY drug. We will reply promptly to your request.
What you should know about brand and generic drug alternates.
Prescription drugs are a costly medical expense, especially for the elderly, those who are chronically ill and those with no or minimal drug coverage on their Health Insurance. However, each state in America has a law that allows pharmacists to substitute less expensive generic drugs for many brand name products. Depending on your prescription needs, your savings could be very significant. Before you talk with your doctor or pharmacist about switching, there are things you should know about generic drugs.
What is the difference between a generic and brand name drug?
Nothing except for the name, packaging, and the price, a generic drug is called by its chemical name; manufacturers assign their own brand name. The generic products have the same ingredients. Standard practice and most state laws require that a generic drug be generically equivalent to its brand name counterpart. That is, it must have the same active ingredients, strength, and dosage form, be it a pill, liquid, or injection. The generic drug also must be therapeutically equivalent. It must be the same drug chemically and have the same medical effect.
Do all drugs have generic equivalents?
No. Some drugs are protected by patents and are supplied by only one company. However, when the patent expires, other manufacturers can produce its generic version. Currently, about half the drugs on the market are available in generic form.
Will my doctor automatically prescribe generic drugs?
It depends on the physician. You can ask your doctor to write a prescription permitting substitution of a generic drug product when appropriate or to define the chemical name for the prescription. This will ensure you are purchasing the correct Mexico drug. Generic products will be as effective and less costly. Or, you can order only brand name products if you wish. www.MedsMex.com.com Mexico pharmacy offers a wide selection of both Brand Name & Generic Mexico medicine. Our Mexican generic drugs are of the highest quality, selected only from the most reputable manufacturers, and are safe to replace brand name medications costing much more.
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