Metformin: instructions
Metformin is a drug that lowers blood sugar levels. It belongs to the pharmaceutical group of oral hypoglycemic drugs from the biguanides (dimethylbiguanide) group.
Mechanisms of action of Metformin:
- Increases immunity to excess glucose - correction of prediabetes (predisposition, risk factors);
- Reduces the absorption of glucose in the intestine (excess sugar does not enter the bloodstream);
- Metformin increases cellular sensitivity to insulin;
- Reduces the production of glucose in the liver (prevents the formation of excess glycogen - energy "stock", prevents lipogenesis - the processing of excess glycogen into fat);
- Reduces triglyceride, LDL and cholesterol concentrations without affecting "good" cholesterol.
Metformin 750 mg is indicated for the treatment of type 2 insulin-independent diabetes, especially in overweight patients in whom diet therapy and exercise only cannot ensure adequate normoglycemia.
In adults, Metformin may be used as monotherapy, in combination with other oral antidiabetic agents or with insulin.
Indications for Metformin
The drug is prescribed for the following indications:
- type II diabetes mellitus with ineffectiveness of diet therapy and physical activity regimen, especially in patients with excess body weight;
- as monotherapy or combined therapy together with other oral hypoglycemic agents or together with insulin for the treatment of adults;
- complications of diabetes in adult patients with type II diabetes mellitus and excess body weight used Metformin as a first-line drug after ineffective diet therapy.
You can buy Metformin online in our online pharmacy. The site specifies the price, availability and basic information about the drug. In addition, buying Metformin online is not only profitable, but also convenient, because you can make an order at any time.
Metformin for weight loss
The main action of Metformin is to lower blood glucose concentrations and increase tissue sensitivity to insulin, which plays an important role in reducing body weight.
The doctor for weight correction recommends Metformin only to those who suffer from diabetes and excessive obesity accompanying this disease, as the drug is prescribed on a permanent basis. You can order online Metformin in our pharmacy at a good price.
Foods to avoid when taking Metformin?
Do not combine Metformin with foods such as:
- Alcohol. Ethanol stimulates the release of insulin and blocks glucose synthesis - thereby lowering blood sugar levels for a short time. Metformin also lowers sugar. Taking them together can lead to hypoglycemia, unconsciousness, and even a hypoglycemic coma.
- Grapefruit and pomegranate juice. Both juices block the CYP3A enzyme that metabolizes Metformin in the liver. This can cause hypoglycemia, as Metformin accumulates and increases its effects. Lactoacidosis is also more likely to occur as a side effect of the drug.
- Fast carbohydrates: sugar, candy, and sweet sparkling water. When fast carbohydrates are consumed, the blood sugar level rises dramatically. Accordingly, more insulin is needed to dispose of it. The standard dose of metformin becomes ineffective, since so much glucose is produced.
- Products with E412 additive: ham, wieners, pate. This is a preservative guar gum, which is used in the food industry as a stabilizer, thickener, and structurer. Products with this additive can block the absorption of Metformin. This decreases the effectiveness of diabetes treatment.
Metformin and alcohol
The instructions for Metformin state that it is not recommended to take the pills at the same time as taking alcohol. This is because intoxication with alcohol increases the risk of lactoacidosis. The greatest danger threatens people who have liver failure.
If alcohol is consumed simultaneously with Metformin, it is possible that glucose levels will become critically low. A person under the influence of alcohol may not realize they are hypoglycemic.
After all, a critically low sugar level produces the same symptoms as intoxication. If this is not taken into account, glucose levels will continue to decrease, resulting in a hypoglycemic coma.
Does Metformin cause diarrhea?
Metformin causes a side effect in the form of diarrhea. The reason is that the drug acts in the small intestine by blocking glucose absorption. This is very important in the treatment of diabetes because it does not raise blood sugar. But this is what causes the fermentation and accumulation of gas in the large intestine.
Most often the stool disorder begins with the first days of taking the drug and lasts for 2-3 weeks. These unpleasant phenomena usually go away in 2 weeks. Metformin has no effect on disruption of intestinal microflora.
Contraindications of Metformin
Consult your doctor before use, because the drug has contraindications:
- Hypersensitivity to Metformin or any other component of the drug
- Any type of acute metabolic acidosis (e.g. lactatoacidosis, diabetic ketoacidosis)
- Diabetic precoma
- Severe renal and hepatic failure
- Dehydration of the body
- Severe infectious diseases
- Decompensated heart failure, respiratory failure, myocardial infarction
- Acute alcohol intoxication, alcoholism
- During the postoperative period, recovery from trauma
- Taking radioactive iodine preparations
- Pregnancy and the period of breastfeeding
You can Metformin order online, but consult your doctor before doing so, as the drug is not recommended for children under 12 years old and the elderly over 65. Also, Metformin preparations may lead to lactacidosis if the patient performs heavy physical work or engages in sports where high exertion is required.
What is the best time to take Metformin?
Metformin should be taken with or after meals to avoid the development of side effects that affect digestion.
Take 1 Metformin tablet per day with 100-150 ml of water. If you take the medicine in divided doses twice a day, take Metformin in the morning (at breakfast) and in the evening (at dinner time).
Metformin in prediabetes
Metformin provides lowering of blood sugar levels. The drug is used in prediabetes to prevent the onset of diabetes.
Does Metformin cause hair loss?
Metformin can increase the risk of side effects associated with vitamin B12 deficiency. If you are taking Metformin and you notice hair loss, talk to your doctor about adding foods that contain vitamin B12 to your diet, such as: beef, fish, eggs, milk. Your doctor may also recommend a vitamin B12 supplement.
Half-life of Metformin
The action of the drug begins 2-2.5 hours after intake. Metformin is excreted by the kidneys and has an average plasma elimination half-life of 4.0 to 8.7 hours after oral administration.
When to take Metformin before or after meals?
Metformin tablets are best taken with a meal or right after to reduce the chance of side effects. Swallow the tablets whole with water.
Foods that cause diarrhea with Metformin
Do not consume these foods during treatment with Metformin, as they may cause a side effect of diarrhea:
- fatty food;
- spicy food;
- fruits;
- dairy products;
- sugar substitutes (such as aspartame);
- coffee.
In cases of dehydration (severe diarrhea or vomiting, fever, or decreased fluid intake) Metformin should be temporarily stopped and a physician should be consulted.
What drugs should not be taken with Metformin?
You can buy Metformin in our online pharmacy. Read the instructions before use, as it is incompatible with many drugs that weaken the effectiveness of Metformin, making it almost useless:
- diuretics;
- corticosteroids;
- thyroid hormones;
- oral contraceptives (estrogen);
- calcium antagonists (heart rhythm regulators);
- nicotinic acid (vitamin B3).
- sympathomimetics.
Anticonvulsants also do not combine with Metformin, especially Phenytoin and its analogues.
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Did you know that your private medical file can be used against you to raise your insurance rates or in some cases and countries to lose your job? We take your privacy very seriously and by using these payment methods and the way in which we use them your bank does not directly get charged from our pharmacy. This way your medical needs stay as private as possible.
You will also receive a complete invoice in your email with payment totals and simple payment instructions toward the bottom of the email should you wish to pay at a later convenience.
IMPORTANT: If you need to make some changes in regards an existing order, contact us within 24 hours, otherwise, Meds Mex is not liable due to errors on customer’s information or products presentation.
Shipping Methods.
To ensure the delivery of your order we handle EXPRESS SHIPPING only. Signature is required.
Tracking numbers for all orders will be sent with instructions once shipped.
How long does it take to ship the drugs to my home or office?
- Express USA time frame: 10-21 business days. ($24.95 USD Signature required)
- Express World Wide time frame: 15-30 business days. ($39.95 USD Signature required)
*Due to unexpected Postal Service changes, one of the shipping methods above could be temporarily disabled.
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Online pharmacy Medicines Mexico shipping terms and conditions.
Our team endeavors to process all orders and ship within 72 business hours. All credit card and electronic check payments for your Mexico medicine take 24 to 48 hours to be approved by our Payment Processor; upon verification your order will be processed. If there are any problems with your order, we will contact you, so please ensure the email address and phone number you provide is correct, and that any spam filtering software you use accepts email from info@medsmex.com.mx
Express Shipping.
We offer Mex Post Express Shipping as an option. This option costs from $24.95 depending on the quantity of medications in your order (up to 9 medications). This option requires a customer signature on delivery. For all other locations Express Shipping is $39.95. All packages are shipped in plain packaging to guarantee your privacy. All packages are sent by parcel express mail from Mexico. Some parcels require a signature upon delivery at our discretion. There are no other handling fees, drug dispensing fees, or Mexican customs charges. If two or more people are ordering their prescription drugs from the same address at the same time, you will be billed for only one shipping charge from our Mexico pharmacy, up to our maximum order quantities limited by customs to 90 day supply. We are able to provide a tracking number on your express shipping parcels. If after 30 business days your order has not arrived, first check with your local postal office to ensure that your package is not being held for pick-up. If you still have problems, please contact us by email and we will attempt to assist you.
Notice Left
If no one is at home at the time of delivery, the status of you order on the Postal System will be updated to “Notice Left” which means USPS attempted to deliver your item and a notice was left because an authorized recipient was not available. You may arrange redelivery by visiting or calling 800-ASK-USPS, or may pick up the item at the Post Office indicated on the notice. If this item is unclaimed after five days then it will be returned to the sender. You can pay for reshipping $24.95 in order to receive a new tracking number. (Reshipping will be issued until the package is received back in our offices).
Holidays
Note that on Holidays season, the Mexican Postal, USA and other countries will be extra busy; therefore a delay is expected in packages shipped during this season. You will need to consider as well the Mexican holidays. We appreciate your understanding, our customer service will be happy to assist you and available to inform you the latest status on your existing order shipped, you can always contact us at Toll Free number or email address.
Order Cancellation
Due to our policy of same day payment processing, ORDERS CANNOT BE CANCELLED.
Returns
Due to government regulations and the possibility of tampering with medications, returns cannot be accepted. In case your package is returned due to no one was available to sign for it. You can pay for reshipping $24.95 in order to receive a new tracking number. (Reshipping will be issued until the package is received back in our offices).
How to find the online pharmacy drug you need.
There are many more medications available in Mexico that are not listed on our website. If you can’t find the Mexican drug or medication you require, please contact us and we may be able to help. Some products are listed only in a single dosage size or medicine type, but may be available in other dosages and forms. Our experienced Mexican pharmacy Pharmacists will do their best to accommodate your requirements. Please always specify the chemical name of the medication (and any applicable brand name) with all inquiries. Please feel free to ask about ANY drug. We will reply promptly to your request.
What you should know about brand and generic drug alternates.
Prescription drugs are a costly medical expense, especially for the elderly, those who are chronically ill and those with no or minimal drug coverage on their Health Insurance. However, each state in America has a law that allows pharmacists to substitute less expensive generic drugs for many brand name products. Depending on your prescription needs, your savings could be very significant. Before you talk with your doctor or pharmacist about switching, there are things you should know about generic drugs.
What is the difference between a generic and brand name drug?
Nothing except for the name, packaging, and the price, a generic drug is called by its chemical name; manufacturers assign their own brand name. The generic products have the same ingredients. Standard practice and most state laws require that a generic drug be generically equivalent to its brand name counterpart. That is, it must have the same active ingredients, strength, and dosage form, be it a pill, liquid, or injection. The generic drug also must be therapeutically equivalent. It must be the same drug chemically and have the same medical effect.
Do all drugs have generic equivalents?
No. Some drugs are protected by patents and are supplied by only one company. However, when the patent expires, other manufacturers can produce its generic version. Currently, about half the drugs on the market are available in generic form.
Will my doctor automatically prescribe generic drugs?
It depends on the physician. You can ask your doctor to write a prescription permitting substitution of a generic drug product when appropriate or to define the chemical name for the prescription. This will ensure you are purchasing the correct Mexico drug. Generic products will be as effective and less costly. Or, you can order only brand name products if you wish. www.MedsMex.com.com Mexico pharmacy offers a wide selection of both Brand Name & Generic Mexico medicine. Our Mexican generic drugs are of the highest quality, selected only from the most reputable manufacturers, and are safe to replace brand name medications costing much more.
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